Postdoctoral Fellowship: Postdoc in Developing High-Throughput Genome Editing Tools for Automated Gene Deletions – BRIGHT

About the Role

This postdoctoral fellowship offers an exciting opportunity to advance high-throughput CRISPR-based genome editing for automated gene deletions, within the BRIGHT initiative at the Technical University of Denmark (DTU). The multi-year project aims to develop robust microbial cell factories and scalable bioprocesses that convert CO₂‑derived feedstocks into high-volume chemicals. As a genome editing specialist, you will design portable, organism-agnostic editing tools and libraries that drive both fundamental discoveries and real-world biotechnological applications.

Responsibilities

• Design and optimise CRISPR/Cas strategies for systematic gene deletions, with emphasis on transferability across multiple prokaryotic hosts
• Co-develop automated, high-throughput protocols for genome‑wide library construction in collaboration with the project team
• Build and curate high‑throughput collections of deletion mutants (including genome‑wide knockout mutants) for functional characterisation and strain optimisation
• Analyse mutant libraries using phenotypic and omics‑based approaches
• Contribute to designing and implementing automation‑compatible workflows using liquid‑handling robotics and related platforms
• Collaborate with interdisciplinary team members and disseminate results through publications and presentations

Qualifications

Required Skills and Experience

• A PhD (or equivalent) in microbiology, synthetic biology, biotechnology, or a related field
• Hands‑on experience with CRISPR/Cas genome editing in (non‑model) microbial systems
• Experience with multiple DNA delivery methods (e.g. electroporation, conjugation)
• Interest or experience in laboratory automation and high‑throughput experimental design
• Strong analytical skills; programming experience for data analysis and workflow scripting (e.g. Python) is desirable
• A collaborative mindset, creativity, and excellent English communication skills

Formal Requirement

You must hold a PhD degree (or equivalent) by the start of the appointment.

What We Offer

Employment Terms

• Full‑time position for 2 years; starting date 1 January 2027 (or by mutual agreement)
• Salary according to the collective agreement with the Danish Confederation of Professional Associations; supplements may be negotiated under DTU’s salary structure for scientific staff

The BRIGHT Initiative

BRIGHT (Biotechnology Research Institute for the Green Transition) is a flagship initiative hosted at DTU. It connects biotechnology and bioproduction research, innovation, and education across the entire value chain, with missions in sustainable materials, microbial foods, and microorganisms for net‑zero agriculture.

About DTU

DTU is one of Europe’s leading technical universities, recognised globally for research, education, innovation, and scientific advice. The university offers an international, collegial environment with academic freedom and responsibility.

How to Apply

Submit your complete online application no later than 2 August 2026 (23:59 Danish time). Applications must be in English and assembled as a single PDF file containing:

• Application (cover letter)
• CV
• Academic diplomas (MSc/PhD – in English)
• List of publications
• Contact details of two reference persons

Use the online application form (linked on the DTU careers page) to upload your PDF. Applications received after the deadline will not be considered. All interested candidates are encouraged to apply regardless of age, gender, disability, race, religion, or ethnic background. Note that because DTU works with research in critical technology, open‑source background checks may be conducted on qualified candidates.

For further information, contact Enrico Orsi ([email protected]).

Original vacancy