Postdoctoral Fellowship: Postdoc in SERS Biosensor Development — Singapore Institute of Technology

Original title: Research Fellow (Biosensor) – AW4

About the role

The Singapore Institute of Technology (SIT) is a University of Applied Learning that works closely with industry in its research pursuits. Research staff gain applied research skill sets that are relevant to industry demands while contributing to active research projects.

This fixed-term Research Fellow position sits within the Food, Chemical and Biotechnology division. The Research Fellow will lead the development of a Surface-Enhanced Raman Spectroscopy (SERS) biosensor platform for rapid detection of microbial bioburden in biopharmaceutical cleaning validation processes. The role encompasses aptamer discovery, nanomaterial-based SERS sensor development, and integration with microfluidic systems for real-time monitoring of cleaning validation washout fluids. Opportunities to contribute to patent filings, translational research, and commercialization pathways are available.

Responsibilities

Technical responsibilities

• Design and screen high-affinity ssDNA aptamers targeting environmental microorganisms listed in the US Pharmacopeia.
• Develop nanoparticle-based SERS substrates (Ag/Au nanoclusters) for enhanced Raman signal detection.
• Design and fabricate microfluidic sensing interfaces for continuous monitoring of cleaning validation fluids.
• Perform sensor validation using Raman spectroscopy, microbial cultures, and cleaning validation samples.
• Develop data analysis pipelines for Raman spectral classification, potentially integrating machine learning methods.

Research and project responsibilities

• Plan and execute experimental workflows to achieve project milestones.
• Lead prototype development and performance optimization of the SERS biosensor system.
• Communicate research outcomes through technical reports, conference presentations, and scientific publications.
• Collaborate with industry partners and interdisciplinary research teams where applicable.

Operational and mentorship responsibilities

• Conduct risk assessments and ensure compliance with Work Safety and Health (WSH) regulations.
• Manage procurement of specialized equipment and research consumables.
• Mentor research engineers, graduate students, and undergraduate researchers.
• Contribute to training activities within the research group.
• Communicate with relevant internal or external stakeholders to ensure project deliverables are met.
• Perform any ad-hoc duties assigned by the Supervisor.

Job requirements

Essential qualifications and experience

• PhD in Bioengineering, Chemical Engineering, Materials Science, Nanotechnology, Analytical Chemistry, or related fields.
• Strong publication record in biosensors, nanomaterials, Raman spectroscopy, or microfluidics.
• Demonstrated experience in nanoparticle-based biosensor development or SERS sensing platforms.
• Proficiency in CAD software (e.g., SolidWorks) for microfluidic device design.
• Experience with Raman spectroscopy instrumentation and spectral data analysis.

Preferred experience

• Experience in microfluidic chip fabrication (soft lithography, PDMS, or micro-machining).
• Experience with aptamer selection or molecular recognition elements.
• Experience applying machine learning to spectral data (Raman, LC–MS, or similar).
• Experience working on translational or industry-linked research projects.

What we offer

This role provides an opportunity to work within a university of applied learning on industry-relevant research, develop translational biosensor technologies, and contribute to patent and commercialization efforts. The position includes mentorship of junior researchers and collaboration with industry partners.

How to apply

Applications should be submitted through the Singapore Institute of Technology careers portal. The posting start date is 17 March 2026. Interested candidates are advised to submit their application before the stated closing date on the portal.

Original vacancy